4th TDM of Biologics SYMPOSIUM, 6th December 2024

Therapeutic drug monitoring of biologics: towards personalised medicine

09.00 – 09.30 Introduction: Treatment of chronic inflammatory diseases in a personalised way

Prof. Gertjan Wolbink, Reade, the Netherlands

SESSION 1: Finding the Therapeutic window

Session chairs: Annick de Vries PhD & Prof. Gertjan Wolbink

09.30 – 09.50 Use of TDM of biologics in rheumatology. Beyond the NOR-DRUM/STAR/DMARD/REDUCE Study

Guro L Goll , MD PhD, Diakonhjemmet Hospital, Norway

09.50 – 10.10 Personalised dosing of biologics in IBD

Mark Löwenberg, Md PhD, Amsterdam UMC, the Netherlands

10.10 – 10.30 Overarching concepts in biologics PK and immunogenecity

Floris Loeff, PhD, Sanquin Diagnostic Services, Amsterdam, the Netherlands

10.30 - 11.00 Panel discussion

11.00 - 11.20 Coffee break

SESSION 2: Dosing down

Session chairs: Mark Löwenberg MD PhD & Prof. Phyllis Spuls

11.20 - 11.40 How to use placebo effects for dosing medicines

Prof. Andrea Evers, University Leiden, the Netherlands

11.40 -12.00 Downscale and Stop studies with biologics: CEASE, SIMBA studies

Mees van der Hoff, MD PhD, Amsterdam UMC, the Netherlands

12.00 – 12.20 Dose reduction of dupilumab in atopic dermatitis

Prof. Marjolein de Bruin-Weller, MD PhD, UMC Utrecht, the Netherlands

12.20 - 12.50 Panel discussion

12.50 - 13.40 Lunch

SESSION 3: Model informed precision dosing and pharmacogenetics

Session chairs: Prof. Ron Mathot & Theo Rispens

13.40 - 14.00 Model informed precision dosing in IBD

Erwin Dreesen, PharmD, PhD, KU Leuven, Belgium

14.00 - 14.15 Precision dosing adalimumab- what did we learn from Adorra

Femke Hooijberg, PhD, Reade, the Netherlands

14.15 – 14.30 Modelling based on real life data; does one model fit all biologics?

Stephan van den Berg MSc, Sanquin Research, the Netherlands

14.30 - 15.00 Panel discussioon

15.00 - 15.30 Tea break

SESSION 4: Beyond TDM of antibody biologics

Session chairs: Prof. Geert D'Haens

15.30 - 15.50 Pharmacogenetics in personalised dosing

Prof. Jesse Swen, LUMC, the Netherlands

15.50 - 16.10 Managing anti-drug antibodies and infusion reactions to enzyme replacement therapy in Fabry disease

Mirjam Langeveld, MD PhD, Amsterdam UMC, the Netherlands

16.10 - 16.30 Using biologics in its most efficient way

16.30 - 16.50 Panel discussion

16.50 - 17.00 Adjourn

Floris Loeff, PhD, Mark Löwenberg MD, PhD, Prof. Gertjan Wolbink

17.00 Farewell drinks and network reception