4th TDM of Biologics SYMPOSIUM, 6th December 2024

Therapeutic drug monitoring of biologics: towards personalised medicine

09.00 – 09.20 Introduction: Treatment of chronic inflammatory diseases in a personalised way

Prof. Gertjan Wolbink, Reade, The Netherlands

SESSION 1a: Finding the Therapeutic window

Session chairs: Annick de Vries & Gertjan Wolbink

09.20 – 09.40 Use of TDM of biologics in rheumatology. Beyond the NOR-DRUM/STAR/DMARD/REDUCE Study

Guro L Goll , MD PhD, Diakonhjemmet Hospital, Norway

09.40 – 10.00 Personalised dosing of biologics in IBD

Mark Löwenberg, Md PhD, Amsterdam UMC, the Netherlands

10.00 – 10.20 Overarching concepts in biologics PK/ADA

Floris Loeff, PhD, Sanquin Diagnostic Services, Amsterdam, the Netherlands

10.20 - 10.40 Panel discussion

10.40 - 11.00 Coffee break

SESSION 1b: Dosing down

11.00 - 11.20 How to use placebo effects for dosing medicines

Prof. Andrea Evers, University Leiden, the Netherlands

11.20 -11.40 Downscale and Stop studies met biologics: CEASE, SIMBA studies

Mees van der Hoff, MD PhD, Amsterdam UMC, the Netherlands

11.40 – 12.00 Dose reduction of dupilumab in atopic dermatitis

Prof. Marjolein de Bruin-Weller, MD PhD, UMC Utrecht, the Netherlands

12.00 - 12.20 Panel discussion

12.20 - 13.20 Lunch

SESSION 2: Model informed precision dosing and pharmacogenetics

Session chairs:

13.20 - 13.50 Model informed precision dosing in IBD

Erwin Dreesen, PharmD, PhD, KU Leuven, Belgium

13.50 - 14.10 Precision dosing adalimumab- what did we learn from Adorra

Femke Hooijberg, PhD, Reade, the Netherlands

14.10 – 14.30 Pharmacogenetics

14.30 - 14.50 Panel discussioon

14.50 - 15.10 Tea break

SESSION 3: New modalities; best approach to TDM incl impact Immunogenicty

Session chairs

15.10 - 15.30 Caging immunogenicity in the setting of replacement therapy / enzym def

Theo Rispens, PhD Sanquin, Amsterdam, the Netherlands

15.30 - 15.50 Replacement therapy

Mirjam Langeveld, MD PhD, Amsterdam UMC, the Netherlands

15.50 - 16.10 Gene therapy / Cell therapies / CAR-T

16.10 - 16.30 Panel discussion

16.30 - 16.50 Healthy break

SESSION 4: Beyond TDM of Biologics

Session chairs Geert D’Haens, Mark Löwenberg

16.50 - 17.10 The pharmaceutical industry’s/ regulators view on TDM

17.10 - 17.30 Using biologics in its most efficient way

17.30 - 17.50 Panel discussion

18.00 Farewell drinks and network reception